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NEWS
Announcing the Vote
by Members and Student Members
on the
2017 Revision of the Bylaws for
NESACS
at the
2017 Annual Meeting
January 11, 2018
The NESACS Board of Directors invites all members of the American Chemical Society from the Northeastern Section (NESACS) to attend our 2017 NESACS Annual Meeting at Nova Biomedical in Waltham, MA on January 11th to discuss and to vote on the 2017 Revised Bylaws for the Northeastern Section of the American Chemical Society. We have undertaken the revision of our bylaws to enable electronic voting, change some of the vocabulary used, modernize, and comply with the recommendations from the Committee on Constitution and Bylaws from the American Chemical Society.
This advanced notice of the vote is required by our current governing document, and we wish to comply with all announcement requirements and deadlines therein.
Please see the November 2017 issue of The Nucleus and refer to the website (www.nesacs.org) for the proposed version of the NESACS Bylaws (2017) for consideration as well as our past version of our Constitution and Bylaws (1998).
As long as you are a member of the ACS and select “NESACS” as your section, you will be eligible to vote as a member or student member. Under our current rules, neither Society Affiliates nor Local Section Affiliates are eligible to vote on the bylaws.
As you register for the January meeting, your eligibility to vote will be cross-checked with the National ACS, and those eligible to vote will have an indicator (name badge or wrist band) on the day of the event.
If you have any questions, please contact Leland Johnson (chemlee@yahoo.com).
The NESACS Bylaws working group consists of Tom Gilbert, Doris Lewis, Michael Singer, Ruth Tanner, Brian D’Amico, Leland Johnson, and John Podobinski. We wish to also thank Professor Cathy Costello and the National Committee on Constitution and Bylaws for their work and for the very fast revision process on the national level. Many in the working group will be in attendance at the Annual Meeting and we will have a limited discussion period for your questions.

NESACS Constitution and Bylaws up for consideration
and MEMBER VOTE at Annual Meeting
Existing 1998 NESACS Constitution and Bylaws Proposed and Updated 2017 NESACS Bylaws

Inspiring Younger Chemists to become the Future of Science and Leadership
By: Caitlyn L. Mills, NSYCC Chair (caitlyn.mills@nsycc.org)
This past August, twenty-one young chemists and I embarked on an eye-opening, life-changing adventure through the SciFinder Future Leaders program. I first learned about this opportunity from a friend who had participated in the program in the past. The application process involved submitting a CV, a letter of recommendation, and an essay on one’s research and experience with SciFinder. Since I use the application often and wanted a behind-the-scenes look into how it was constructed and maintained, I decided to apply. This prestigious program brought together young chemists, not only with different scientific interests, but from different parts of the world. We were given the unique opportunity to learn the inner workings of the Chemical Abstracts Service (CAS) division of ACS as well as to develop our networks and careers (exponentially).
In the first portion of the program, the Future Leaders gathered at CAS headquarters in Columbus, Ohio, for a fast-paced week filled with workshops, focus groups, and fun! From day one, we were immersed in thought-provoking exercises that brought us out of our shells and closer together. We participated in workshops hosted by CAS staff members on communicating science through innovation, marketing, and presentations. Every session offered valuable information and transferable skills that every scientist can benefit from.
After a few days at CAS, we flew to Washington, DC, for a day at ACS headquarters before the start of the national meeting. While at ACS, we participated in a number of workshops and activities on authoring, leadership, communication, and the reviewing of manuscripts. This experience allowed us to interact with ACS staff as well as learn information directly from the experts.
Finally, the Future Leaders got to experience all that the national meeting had to offer. Many of us also had the opportunity to give poster or oral presentations; I was selected to give an oral presentation during the Graduate Student & Postdoctoral Fellow Symposium hosted by the Division of Biological Chemistry, where I spoke about my current research in protein function annotation using computational methods to predict the function of proteins, and testing these predictions biochemically. This research is crucial to bridge the gap between chemical biology and computational chemistry while providing an approach to functional annotation for wide applications, including drug discovery, alternative energy technology, biofuel production, and controlling antibiotic resistance.
I think I can speak for all of the Future Leaders when I say this program was a once-in-a-lifetime experience that taught us a great deal, not only about ACS and CAS, but also about ourselves as individuals and scientists. The program was intensive and involved long hours over a short period of time, and we all wished we had a little longer. We didn’t want the program to end, and we left with an enormous amount of information, unforgettable experiences, and friendships that will last a lifetime. Each person I met during this program, Future Leaders and members of CAS/ACS, inspired me both professionally and personally. I strongly recommend and encourage all chemistry Ph.D. students and postdoctoral researchers to apply for the SciFinder Future Leaders program. It has been one of the most pivotal moments in my career thus far. For more information, check the CAS webpage (www.cas.org). The application deadline for the next program will be in early 2018. If you would like to learn more about this year’s Future Leaders, check out the article in C&EN (July 31, 2017, pp. 40-42).
Since returning from my trip to CAS and the ACS meeting, I have fully taken over the chair position of NSYCC. At the meeting, we were honored to win a ChemLuminary Award for Outstanding Sustainability Activity for our Green Chemistry workshop that we co-hosted with UMass Boston and Pfizer last year. We also hosted our annual Fall Mixer night in September, which gave young chemists in the Boston area the chance to get together and network while enjoying some friendly competition through chemistry-themed trivia. On November 18, we will hold our Second Annual Fall Career Symposium at Boston University, which will feature workshops for younger chemists from the undergraduate to postdoctoral levels to engage them in resume and CV construction, cover letter writing, and confidence building; panels will provide expert guidance on career paths in academia, industry, and other professions. In addition, a separate program for undergraduates will be held at Bridgewater State University on November 29. For more information on these two events, check the NSYCC webpage (www.nsycc.org).
The NSYCC is planning a number of programs for 2018 as well, including our annual Northeast Student Chemistry Research Conference (NSCRC) and hosting events during the Fall ACS National Meeting in Boston in August. I am very excited for all that NSYCC has to offer and to interact with other young chemists in the area!
Photo by Peter Carlton (CAS)

Editor’s note: Torsten John, a graduate student at the Leibniz Institute of Surface Modification, was a participant in the NESACS-GDCh German Exchange to Boston and New Haven (for NERM) in October 2013.

 

Approved Oncologic Drugs for Pediatric Use 2015-2017
By James S. Weinberg, Ph.D., Biophysics Assay Laboratory

The good news - the FDA has approved 4 new drugs with indications for pediatric oncological use and added them to the original list of 25 drugs published in October 2015 NESACS The Nucleus.
(See) http://www.nesacs.org/curr_events/other-sym/symp/weinberg_symp/andrew_weinberg_symp1995- 2015.pdf
Regulatory Approved Oncologic Drugs for Pediatric Use with Pediatric Dosing 2015-2017
Drug Oncology Drugs Approved - Indication
Dinutuximab
(tradename Unituxin)
Neuroblastoma in combination with GM-CSF and IL-2 and 13-cis retinoic acid
Blinatumomab
(tradename Blincyto)
Relapsed/refractory acute lymphoblastic leukemia
Pembrolizumab
(tradename Kaytruda)
Microsatellite instability-high solid tumors
Avelumab
(tradename Bavencio)
Children 12 years of age and older with Merkle cell carcinoma
This brings the total in the last 64 years (since 1953) to 29 drugs approved (about one every two years). In the last two years the rate has improved to two drugs a year. All four new drugs are monoclonal antibodies: Dinutuximab is a monoclonal antibody that targets glycolipid disialoganglioside (GD2), expressed on neuroblastoma cells. Blinatumomab specifically targets the CD19 antigen present on B cells. Pembrolizumab targets the programmed cell death 1 (PD-1) receptor. Avelumab targets the protein programmed deathligand 1 (PD-L1).
Our 2016 Weinberg Symposium speaker Mignon Loh was deeply involved in the successful pediatric clinical trials of Blinatumomab.

Photo by Sam Ogden

Thanks to major support from Members, contributors to Team Andrew Weinberg Boston Marathon Jimmy Fund Walk, and two major donations from Epizyme®, Inc., and Tufts’ Physician Assistants Class of 2018, we are proud to announce: James E. Bradner, MD, President of the Novartis Institutes for BioMedical Research will give the 21st Andrew H. Weinberg Memorial Lecture on Wednesday, November 1, 2017 at 4:00 pm – 5:00 pm which will be simultaneously web streamed at: http://video.dfcionline.org/accordent/WeinbergSymposium110117
Final information will be in the October issue of The Nucleus, online at MassBio’s event page and online in Whitehead Institute’s Biology Week.
Donations are gratefully accepted at: http:/www.jimmyfundwalk.org/2017/teamandrewweinberg

 
2017 ACS Fellows Named
The ACS has named 65 members as ACS Fellows in the Class of 2017, who will be celebrated at the National Meeting in Washington, DC, in August.  Among them are four from NESACS.
 
Rick Danheiser
Massachusetts Institute of Technology
Contribution to the science/profession: Developed numerous innovative and elegant methodologies, including the Danheiser Annulation, the Danheiser Benzannulation, and cycloadditions of highly unsaturated conjugated molecules for the synthesis of complex carbocyclic and heterocyclic organic compounds.
Contribution to the ACS community: Through for his sustained tenure as Editor-in-Chief of Organic Syntheses, he championed reproducible, independently validated, and practical procedures for useful synthetic transformations. Advocated compellingly for increased reproducibility in chemical research.
   
Arthur Greenberg
University of New Hampshire
Contribution to the science/profession: Recognized for service as journal founder/editor and college administrator and for contributions to the fields of polycyclic aromatics, focusing on analysis, hazards and metabolism, and structural chemistry, especially strained molecules and amides.
Contribution to the ACS community: Recognized as an author of books on the history and image of chemistry. Other contributions include public presentations, volunteer service on professional committees and boards, and educator and Project SEED mentor.
   
Katherine Lee
Pfizer, Inc.
Contribution to the science/profession: As an outstanding medicinal chemist, she has discovered four compounds that have reached Phase II clinical trials. At Pfizer, she led the chemistry team that discovered a first-in-class IRAK4 inhibitor.
Contribution to the ACS community: A leader in the Northeastern Local Section and the Division of Organic Chemistry, she introduced innovative programs to engage younger chemists and help all chemists advance their careers.
   
Irvin Levy
Gordon College
Contribution to the science/profession: Honored for significant contributions in advancing the field of green chemistry education, including expanding the community of green chemists, contributing scientific communications, and increasing student engagement.
Contribution to the ACS community: Recognized for excellence in service to the Division of Chemical Education (CHED), bringing in new, cross-Divisional programming to the CHED program and introducing relevant, green chemistry programming to the Division.
   
They join the more than 1,050 ACS members who have been named as Fellows since 2009 when the program began, including a total of 44 members of NESACS.
For a complete list of ACS Fellows, see <http://www.acs.org/content/dam/acsorg/funding/fellows/acs-fellows-list.xlsx>

 
ACS Announces 2018 Awards
The following NESACS members have been named as winners of awards administered by the ACS for 2018.  With the exception of the Cope Scholars Awardees, these recipients will be honored at the Awards Ceremony on Tuesday, March 20, 2018, in conjunction with the 255th ACS National Meeting in New Orleans, LA.
ACS Award in Applied Polymer Science sponsored by Eastman Chemical: Paula T. Hammond, M.I.T.
ACS Award in Pure Chemistry sponsored by the Alpha Chi Sigma Fraternity and the Alpha Chi Sigma Educational Foundation: Mircea Dinca, M.I.T.
Ronald Breslow Award for Achievement in Biomimetic Chemistry sponsored by the Ronald Breslow Award Endowment: David R. Liu, Harvard University.
Arthur C. Cope Scholar Awards sponsored by the Arthur C. Cope Fund: Emily P. Balskus, Harvard University; James P. Morken, Boston College.
Nobel Laureate Signature Award for Graduate Education in Chemistry sponsored by Avantor™ Performance Materials: Aleksandr V. Zhukhovitskiy (Student), University of California, Berkeley and Jeremiah A. Johnson (Preceptor), M.I.T.
Also, the James Flack Norris Award in Physical Organic Chemistry sponsored by NESACS will be presented to Cynthia J. Burrows, University of Utah.
In addition, our Brauner Memorial Lecturer at National Chemistry Week will be honored:
James T. Grady–James H. Stack Award for Interpreting Chemistry for the Public sponsored by ACS: Bassam Z. Shakhashiri, University of Wisconsin-Madison.
All 2018 ACS Award recipients are listed here ...

Historical Notes
Marietta Schwartz Jean-Pierre Anselme Karen L. Piper
Christine Jaworek-Lopes Vivian Walworth Daniel J. Sandman
Arthur Obermayer Benedict Gallo Haig Markarian
Edwin Emerson Morse Claude Spencer Tommy Menino
David O. Ham Norman J. Hochella Bernard Siegal
Clarence Grant Leon Mir