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Nulabel Technologies

PK/PD/ADME expert

Worcester, MA
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Microbiotix, Inc. seeks a highly motivated full-time or part-time Ph.D. PK/PD/ADME expert. The successful candidate will provide PK/PD/ADME expertise on anti-infective discovery and development project teams. Experience with experimental design, implementation and data interpretation, as well as strategies and tactics to advance high-quality small molecules is essential. PK/PD/ADME experience with anti-bacterial and anti-viral small molecules would be desirable, but not mandatory. As part of a multidisciplinary team, and as an interface with CROs, organization and communication skills will be paramount. The candidate should have a strong understanding of DMPK and PK/PD areas applicable to animal models and translation into humans and will lead the DMPK function for discovery projects from early target validation stages, into the nomination of the development candidate, and through support of clinical studies. Duties will include planning and directing studies; gathering, analyzing, interpreting and disseminating DMPK and PK/PD data; and standardizing drug doses. Candidates are expected to have industry experience with both in vitro ADME and small animal in vivo assessments (tolerability, PK, PK/PD modelling and simple efficacy studies). Candidate should be familiar with standard analytical methods (HPLC, LC-MS) and basic DMPK modelling (WinNonLin, etc.). Microbiotix, Inc. is an equal opportunity employer, and offers competitive compensation and benefits. This position could be a combination of telecommuting and in office, as personal needs or location dictates.

  • Analytical – supervise in vitro ADME studies, perform DMPK modelling calculations
  • DMPK—design and interpret PK, PK/PD, tolerability, anti-infective efficacy studies in mice
  • Project management—work with senior personnel to accomplish tasks and plan future studies
  • Communication—written(manuscripts,grantapplications)andoral(labmeetings,projectmeetings)
  • Designing and executing preclinical studies to understand the ADME and PK characteristics of development candidates
  • RepresentDMPKasthesubjectmatterexpertonmultidisciplinaryprojectteams
  • The analysis and interpretation of preclinical DMPK data
  • Manage external vendors in the conduct of in vitro/in vivo ADME studies
  • Establish ADME strategies that meet regulatory requirements and program goals
  • Ph.D or Pharm.D in Pharmacokinetics or related discipline (e.g. Pharmacology, Toxicology, Biology, Biochemistry, Pharmaceutical Science, Drug Metabolism).
  • 5+ years (industrial preferred)

About Microbiotix:
Microbiotix, Inc. is a biopharmaceutical company focused on the discovery and development of proprietary small molecule drugs that target serious infectious diseases. Microbiotix has active projects in the antibacterial, antiviral, and antiparasitic areas, including many diseases that are underserved by the pharmaceutical industry, and we collaborate extensively with academic investigators to solve complex problems in these areas.
The Company's lead therapeutic compound, MBX-400, a novel agent for the treatment of human cytomegalovirus, is currently in Phase IB clinical testing. MBX-400 is a non-natural nucleoside analog that has shown improved activity against resistant strains and less toxicity than existing HCMV therapies.
To Apply:
Please e-mail resumes to our employment inbox ( Please include PK/PD/ADME in the subject line. We thank all applicants for their interest, however due to the volume of applicants, we will only contact those applicants with whom we are scheduling an interview. All attachments must be sent in either .pdf (preferred) or .doc format.