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Research Associate II, Medicinal Chemistry
Position Title:
Research Associate II, Medicinal Chemistry
Location: Broad Institute - Cambridge
Region: Massachusetts
Requisition Number: 2638
To Apply: Click Here ...

Job Description:
The Broad Institute is an amazing place - we exist to apply our deep knowledge of human genetics to empower a revolution in biomedicine and accelerate the pace at which the world conquers disease.
Embedded within the Broad Institute, the Center for the Development of Therapeutics (CDoT) is a highly collaborative organization of professional scientists that, in its structure, capabilities and partnerships, functions similarly to a small pharma or biotech. Our mission is to take on bold and ambitious therapeutics projects that have the potential to benefit patients and influence drug discovery more broadly. We do this by translating cutting edge biological insights originating from human biology into drug discovery projects by collaborating with Broad principal investigators and industrial partners, leveraging the expertise of both. We utilize systematic approaches in genomics, biology, and chemistry, coupled with the Broad's culture of creativity, risk-taking, and open sharing, to successfully advance science, develop new treatments, and positively impact patients.
We are looking for a highly motivated and talented chemist to work within a larger team of medicinal chemists, both within the Broad Institute and industrial partners, focused on discovering novel therapeutics. The position is primarily focused on synthesizing novel small molecules to enable oncology drug discovery efforts.  As a lab-intensive role, the successful candidate will be responsible for efficiently producing key chemical matter (including compound libraries), planning and optimizing reactions, as well as characterizing and analyzing results. The candidate will need to understand project-specific milestones/priorities and deliver results accordingly. Additionally, the candidate will need to attend and contribute to planning meetings, maintain clear experimental records, and contribute to laboratory equipment upkeep.

  • Bachelor’s degree in chemistry with 2+ years of research experience or a Master’s degree in chemistry with optional experience in medicinal chemistry.
  • Technical expertise in multi-step synthesis, including purification (flash chromatography, HPLC, recrystallization, etc.) and compound characterization (LC-MS, NMR).
  • Specific technical expertise in standard metal-catalyzed organic synthesis (Suzuki, Sonogashira).
  • Ability to work independently, as well as analyze, interpret, and present results.
  • Ability to plan synthetic routes.
  • Familiarity with relevant software such as ChemDraw or SciFinder/Reaxys
  • Preferred ability to troubleshoot synthetic issues supported by a strong mechanistic understanding.
  • Must have strong interpersonal and communication skills.

The Broad Institute will not offer visa sponsorship for this opportunity.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

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Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled
The Broad Institute is pioneering a new model of collaborative biomedical science to transform biology and medicine. To do that, we have created a unique community of amazing, creative people — “Broadies” — each with a passion for pushing scientific frontiers.
Broadies have a diverse collection of talents, expertise, and backgrounds, creating a rich collaborative environment for solving intractable scientific problems. We are always looking for new team members within Research, Computational Biology, Software Engineering, and Administration to help us tackle important problems at the cutting edge of science.
Why Broad?
It comes down to our culture. Our community transcends academic and organizational barriers, encouraging different points of view and making all Broadies part of something meaningful.
If ours is a community you would want to be a part of, then please apply!