This is an all day symposium. The science will focus on cutting edge research in Process Chemistry from both academic and industry labs in the areas of catalysis, mechanistic understanding, green chemistry, and process scale-up. The symposium will be followed by a reception with appetizers and refreshments for the symposium speakers and attendees.

How to get there:

1. We encourage people to carpool if possible. Driving, use 500 Shire Way, Lexington, MA 02421 in your GPS to find the parking lot.  The parking lot is approximately 0.4 miles (8-10 min estimated walk) to 200 Shire where registration is located.
2. Uber/Lyft, use 300 Shire Way for drop off point.  Note: Registration is at 200 Shire Way. There will be signage to direct people.
3. Nearest MBTA stop: Alewife T Station followed by A1 Alewife shuttles. There are only two trips for people coming to the symposium if they want to be on-time for the first speaker. 7:20 and 7:50. Please note: we do not guarantee space on these shuttles and there are regular riders who are likely to be riding at the same time. You may take Uber/Lyft if the shuttle is full.

Agenda:

8:00 AM            Breakfast

Morning Session

8:30 AM            Welcome & Introductory Remarks

Erin O’Brien (Takeda)

8:40 AM            Jeff Bode (ETH Zurich)

Unconventional Amide Forming Reactions for the Synthesis of Peptides, proteins, and Bioconjugates 

9:40 AM            Heather Johnson (Amgen)

Development of a Process to Manufacture a GalNAc siRNA Targeting Ligand on Multi-kilogram Scale

10:10 AM          Break

10:30 AM          Thomas Toupy (Takeda)

Closing the Gap in Continuous Manufacturing: From Feedback Control to Real-Time Process

11:00 AM          Connor Coley (MIT)

Predictive Chemistry, Computer-aided Synthesis Planning, and Opportunities for Process Chemistry

12:00 PM          Lunch

Afternoon Session

1:30 PM            Patricia Musacchio (U. Buffalo)

A Redesigned Approach to Accessing Carbocations

2:30 PM            David Stephens (Vertex)

Aqueous Decarboxylation Facilitated by Data Rich Experimentation

3:00 PM            Break

3:20 PM            Andreas R. Rötheli (Sanofi)

Leveraging Automation & Modeling to Accelerate Process Understanding

3:50 PM            Hans Renata (Rice)

Biocatalytic & Chemoenzymatic Strategies for Accessing Privileged Small Molecules

4:50 PM            Closing Remarks

5:00 PM            Reception

7:00 PM            Close of Reception and Event

 

Registration and more details at: https://2024_NESACS_Process_Chemistry_Symposium.eventbrite.com