Third Annual “Chemical Biology in The HUB” Symposium

This third-in-a-series of scientific talks will focus on cutting edge research in Chemical Biology from both academic and industry labs in the areas of translational chemical biology, machine learning, novel target identification and validation, chemical imaging, as well as new chemical modalities.

This day-long symposium will be followed by a reception with appetizers and refreshments for the symposium speakers and attendees.

We wish to thank all of the sponsors and volunteers from industry who are making this possible. Our sponsors include, in alphabetical order, The American Chemical Society, ACS Chemical Biology, ACS Central Science, Arrakis Therapeutics, AstraZeneca, Biogen, C4 Therapeutics, Celgene, Jnana Therapeutics, Millipore Sigma, New England BioLabs, Northeastern Section of the ACS, Novartis, Pfizer, Sanofi, Vertex. Our organizers are pleased to continue this fall tradition this year and in the coming years; please be in contact with us (below) if you are interested in participating in future symposia through volunteering, through sponsorship, or other means.

Registration is required and a ticket will be necessary for admission to the symposium and the networking reception. There are several parking lots located in the area close to Merck.

Registration or other questions? Please contact: Andrew Scholte, Chair of NESACS, ascholte@gmail.com

Schedule of Events

8:30 – 9:00 Check-in

9:00 – 9:10 Welcome-Introductory Remarks – Erik Hett

9:10 – 9:25 Trends and future of chemical biology – Milka Kostic (DFCI)

9:25 – 10:05 The power and limitations of learned molecular representations – Regina Barzilay (MIT)

10:05 – 10:45 Applications of artificial intelligence in drug discovery-separating hype from utility – Pat Walters (Relay Therapeutics)

10:45 – 11:05 Coffee Break

11:05 – 11:45 Lysosome targeting chimeras (LYTACs) as a new therapeutic modality – Carolyn Bertozzi (Stanford University)

11:45 – 12:25 Mapping of immunomodulatory receptor protein interactions via photoactivation-based proximity labelling of the cell surface – Niyi Fadeyi and Rob Oslund (Merck)

12:25 – 1:30 Lunch

1:30 – 1:45 Small tools to answer big questions-advancing chemical biology through innovative chemistry – Chris am Ende (Pfizer)

1:45 – 2:25 Chemical probes of transcription factors – Angela Koehler (MIT)

2:25 – 3:05 Solving a 60 year mystery: SALL4 mediates tetratogenicity as a thalidomide-dependent substrate of cereblon Mary Matyskiela (Celgene)

3:05 – 3:25 Coffee Break

3:25 – 4:05 Quantitative chemical imaging in live cells – Yamuna Krishnan (U of Chicago)

4:05 – 4:45 Chemical Biology: An essential pillar in Drug Discovery? – Mark Bunnage (Vertex)

4:45 – 4:55 Concluding remarks and looking to 2020 – Erik Hett (Merck) & Jaimeen Majmudar (Pfizer)

4:05 – 4:45 Chemical Biology: An essential pillar in Drug Discovery? – Mark Bunnage (Vertex)

5:00 – 6:00 Reception and Poster Session

Questions? Please contact: Andrew Scholte, ascholte@gmail.com.

THE PUBLIC IS INVITED – RESERVATIONS ARE REQUIRED

FAQs

What are my transport/parking options getting to the event?

Merck Research Laboratories is located in the Longwood Medical Area and is walking distance from the D-line (Fenway Stop) and E-line (Museum of Fine Arts) of the Green Line. There are also numerous parking garages in the area.

Please contact the organizers regarding carpooling and other options.

For driving directions from where you will begin your trip, enter “33 Avenue Louis Pasteur, Boston, MA 02115,”

Where can I contact the organizer with any questions?

With any questions whatsoever, please contact Andrew Scholte, ascholte@gmail.com

Is my registration/ticket transferrable?

Yes, please contact Andrew Scholte before September 12, 2019.

The power and limitations of learned Regina Barzilay (MIT) Auditorium

molecular representations