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Chemical Biology in the HUB 2023

September 14, 2023 @ 8:00 am - 6:00 pm


Chemical Biology in the HUB

Sept 14th, 2023

The Broad Institute 415 Main St Cambridge, MA 02142

LINK for registration via Eventbrite.


Chemical Biology in The HUB Symposium

This fifth-in-a-series of scientific talks will focus on cutting edge research in Chemical Biology from both academic and industry labs in the areas of translational chemical biology, machine learning, novel target identification and validation, chemical imaging, as well as new chemical modalities.

This day-long symposium will be followed by a reception with appetizers and refreshments for the symposium speakers and attendees.

We wish to thank all of the sponsors and volunteers from industry who are making this possible. Our sponsors include, in alphabetical order, The American Chemical Society, ACS Chemical Biology, ACS Central Science, Arrakis Therapeutics, AstraZeneca, Biogen, BMS, C4 Therapeutics, FogPharma, GSK, Jnana Therapeutics, Kymera, Merck, Northeastern Section of the ACS, Novartis, Pfizer, Sanofi, Vertex. Our organizers are pleased to continue this fall tradition this year and in the coming years; please be in contact with us (below) if you are interested in participating in future symposia through volunteering, through sponsorship, or other means.

Registration is required and a ticket will be necessary for admission to the symposium and the networking reception

Schedule of Events 

8:15 – 9:00 am Registration and coffee

9:00 – 9:10 am Opening remarks

9:10 – 9:45 am Ed Chouchani, Harvard University

Systematic discovery of druggable redox switches on immunological proteins

9:45 – 10:20 am Danette Daniels, Foghorn Therapeutics

Targeting Chromatin Regulatory Proteins with Therapeutic Degraders

10:20 – 10:45 am Coffee Break

10:45 – 11:20 am Keriann Backus, UCLA

Global rewiring of the proteome by cysteine-reactive electrophiles

11:20 – 11:55 am Ben Ruprecht, Covant Therapeutics

Leaving a permanent mark – Harnessing covalent chemoproteomics to target native proteoforms

11:55 am – 1:00 pm Lunch

1:00 – 1:35 pm Justin Kim, DFCI

Bioorthogonally activated reactive species for target identification

1:35 – 2:10 pm Heather Murrey, Scorpion Therapeutics

Advances in Covalent Ligand Discovery Enable Development of New Cancer Therapeutics

2:10 – 2:45 pm Justin Rettenmaier & Matt Labenski, Jnana Therapeutics

RAPID: photoaffinity-based high-throughput ligand discovery in cells

2:45 – 3:05 pm Coffee break

3:05 – 3:40 pm Jonathan Hurov, FogPharma

Development of Stapled Peptide HeliconsTM for Inhibition of β-Catenin:TCF Interaction

3:40 – 4:15 pm Michelle Arkin, UCSF

Structure, function, and manipulation of ‘hub’ proteins and their partners

4:15 – 4:20 pm Closing remarks

4:20 – 6:30 pm Poster session and reception


Questions? Please contact: Jeremy Baryza, jeremy_baryza@vrtx.com



What are my transport/parking options getting to the event?

The Broad is located in the heart of Kendall Square and is walking distance from the Kendall Square T-stop of the Red Line. There are also numerous parking garages in the area. 

Please contact the organizers regarding carpooling and other options.

For driving directions from where you will begin your trip, enter “415 Main St, Cambridge, MA 02142”

Is my registration/ticket transferrable?

Yes, please contact Jeremy Baryza before September 12, 2022.

Additionally there will be a poster session and ample time for discussion, networking, and catching up with colleagues and friends.

Please come join us for our 5th year!


Chemical Biology Committee
View Organizer Website


The Broad Institute
415 Main St
Cambridge, MA 02142 United States
+ Google Map


Chemical Biology Committee
View Organizer Website


The Broad Institute
415 Main St
Cambridge, MA 02142 United States
+ Google Map