The 1034th NESACS Meeting jointly with
the 2024 Medicinal Chemistry Symposium
“Contemporary Methods in Medicinal Chemistry”

3:15 pm Welcome: Raj Rajur, Medicinal Chemistry Program Chair – CreaGen, Woburn, MA

3:20 pm – Introductory Remarks from Takeda

3:30 pm – 4:00 pm – Presentation: Ryan Kerrigan – Novartis

Title: “First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor to Treat Sickle Cell Disease”

4:00 pm – 4:45 pm – Presentation: Michelle Garnsey – Pfizer

Title: “Discovery of SARS-CoV-2 papain-like protease (PLpro) inhibitors with efficacy in a murine infection model”

4:45 – 5:00 pm – Break

5:00 pm – 5:45 pm – Presentation: Derun Li – Nimbus

Title: “Designing Selective WRN Covalent Inhibitors from Non-Covalent Binders”

5:45 pm – 6:30 pm – Presentation: Brandon Vara – Merck

Title: “Discovery of MK-4424: a Potent, Exquisitely Selective, and CNS-penetrant RIPK1 Type-III Inhibitor to Treat Neurodegeneration”

6:45 pm – 8:30 pm Dinner

Organizing Committee:

Mark Ashwell; Brian. Aquila; Blaise Lippa; Andrew Scholte; Peter Fuller; Michelle Lamb; Silvana Leit; Melissa Grenier-Davies; Paul Scola; Lauren Monovich; Jason Beiger; Paul Greenspan; Raj Rajur

Registration and more details at: https://2024_Med_Chem_Symposium_and_December_Meeting.eventbrite.com