Avilar – Associate Director or Director or Senior Director of Biochemistry and Biophysics
Avilar is a growing, well-funded start-up biotech pioneering novel aspects of extracellular protein degradation to bring transformational therapies to patients with unmet medical need. The company is backed by RA Capital, a leading health care investor.
We are seeking a Scientist-Leader skilled in biochemistry and/or biophysics to develop new targets using our proprietary extracellular protein degradation platform and explore new avenues to mediate protein degradation. The successful candidate will contribute at numerous points along the drug discovery path, from target selection to development candidate identification. The successful candidate will design and analyze assays to characterize molecules that induce protein degradation using biochemical and biophysical techniques in terms of both activity and mechanism of action.
Activities will include leading existing programs on a critical path, proposing and overseeing new programs, managing vendors and data flow, designing and validating assays, new target analysis, and new platform biology development. The ability to seamlessly multiple, different workstreams with a sense of urgency and ownership will be essential for success.
The successful candidate will be excited to work in a flexible environment, with the opportunity to impact multiple aspects of the drug discovery path and be transparent in communicating with other team members. Scientific depth, curiosity, independence, collaboration and drive are keys aspects of the role.
This role is based in Waltham, Massachusetts.
Contribute to the scientific direction of the company from target selection to novel approaches to protein degradation.
Effectively enable and lead multiple drug discovery programs via the design, implementation, and interpretation of relevant and robust biochemical and biophysical assays.
Oversee the operational management and contracts of external CROs, academic, and business partners and maintain efficient workflows to meet timelines.
Promote an environment of collaboration, teamwork and innovative and robust science.
Ensure compliance with company established practices and procedures, including laboratory notebooks and databases.
Ph.D. degree in biochemistry, biology, pharmacology or related subject. Postdoctoral research experience preferred.
At least 7 years (Associate Director) or 10 years (Director) industry preclinical drug discovery experience such as target validation, hit finding, lead optimization, quantitative data analysis, and mechanism of action studies.
Experience in designing research plans to address specific scientific objectives including prioritization of critical path activities, relevance, risk mitigation, resourcing and timelines.
Strong background in biochemical (e.g., TR-FRET) and/or biophysical (e.g., SPR) assay methods.
Understanding of protein structure and function is a plus.
Knowledge of immunoglobulin structure and biology is a plus
Ability to work seamlessly in a cross-functional matrixed environment with high attention to detail.
Excellent verbal and written communication skills, including strong presentation skills and the ability to communicate complex scientific information in a clear manner to different audiences.
Desire to work in a start-up biotech environment.